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KMID : 1011820150560110785
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Investigative and Clinical Urology
2015 Volume.56 No. 11 p.785 ~ p.787
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Repeated spurious elevation of serum prostate-specific antigen values solved by chemiluminescence analysis: A possible interference by heterophilic antibodies
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Arturo Dominguez
Miquel Bayo
Jesus Munoz-Rodriguez
Jose Antonio Bellido
Jose Maria Abascal-Junquera
Naim Hannaoui
Josep Maria Banus
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Abstract
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Heterophilic antibodies are human immunoglobulins directed against various animal antigens. They can produce false-positive results in the analysis of different tumor markers, including prostate-specific antigen. This interference can lead to misdiagnosis, unnecessary tests, and overtreatment in some cases. We present herein the case of a 52-year-old man with repeated spurious elevation of prostate-specific antigen, reaching levels of 108.7 ng/mL, that were suspected to be caused by heterophilic antibodies. The interference was solved by changing the analysis technique. Real values of prostate-specific antigen were less than 1 ng/mL.
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KEYWORD
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Analysis, Diagnosis, Heterophile antibodies, Immunoassay, Prostate-specific antigen
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